Oncogene Addiction and Synthetic Lethality in BRCA-Mutant Cancers
Document Type : مقاله پژوهشی
Author
Department of Translational Medicine
Abstract
Synthetic lethality exploits tumour-specific dependencies. We performed genome-wide CRISPR screens in BRCA-mutant cancer lines to map DNA-repair vulnerabilities beyond PARP. Loss of POLQ and USP1 emerged as the strongest selective dependencies, and combined inhibition overcame acquired PARP-inhibitor resistance in patient-derived xenografts.
Graphical Abstract
Keywords
Volume 4 (2026), Issue 2
Genomics of CarcinogenesisSpring 2026Pages 78-91
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