Single-Cell Genomics Reveals Clonal Evolution in Colorectal Tumours
Document Type : مقاله پژوهشی
Author
Department of Translational Medicine
Abstract
Intratumoural heterogeneity shapes treatment response. We applied single-cell DNA and RNA sequencing to 36 colorectal tumours spanning disease stages, reconstructing clonal phylogenies at single-cell resolution. Branched evolution dominated in mismatch-repair-proficient tumours, while deficient tumours showed punctuated bursts of mutation. Subclonal diversity at diagnosis predicted shorter progression-free survival independently of stage.
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Volume 4 (2026), Issue 2
Genomics of CarcinogenesisSpring 2026Pages 25-38
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