Telomere Dysfunction Drives Chromosomal Instability in Aggressive Carcinomas
Document Type : مقاله پژوهشی
Authors
1
Department of Translational Medicine
2
School of Biological Sciences
Abstract
Telomere attrition precipitates a state of chromosomal instability that fuels tumour heterogeneity. We characterised telomere dynamics across 312 aggressive carcinomas using long-read sequencing. Tumours with critically short telomeres showed a fivefold excess of fusion-bridge-breakage events, and telomerase reactivation timing separated two distinct evolutionary trajectories.
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Volume 4 (2026), Issue 2
Genomics of CarcinogenesisSpring 2026Pages 133-146
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