Genome-Wide Methylation Landscape Identifies Drivers of Early Carcinogenesis
Document Type : مقاله پژوهشی
Authors
1
Institute of Cancer Genomics
2
Centre for Molecular Oncology
Abstract
Aberrant DNA methylation is an early hallmark of malignant transformation. We profiled the genome-wide methylation landscape of 480 pre-malignant and tumour specimens across six tissue types, identifying 1,284 differentially methylated regions that separate pre-malignant from invasive disease. Hypermethylation of developmental transcription-factor loci emerged as the earliest detectable event, preceding copy-number change in 71% of cases. These findings position methylation profiling as a candidate substrate for early-detection assays.
Graphical Abstract
Keywords
Volume 4 (2026), Issue 2
Genomics of CarcinogenesisSpring 2026Pages 1-12
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